It just might be, according to New York: An Illustrated History, by Ric Burns and James Sanders. Taken at Broadway between Franklin and Leonard Streets, it’s believed to date to May 1850.
Looks like workers have torn up the street. On the far left, at 360 Broadway, is a building advertising carriages, and a block down Broadway is an ad for “Moffat” on the side of a taller structure.
Who was Moffat? John Moffat was a doctor whose “Moffat’s Life Pills and Phoenix Bitters” made him quite wealthy in the mid-19th century. He and his family lived on Union Square, but he also owned the building that bore his name, at 337 Broadway.
Tags: 337 Broadway, Broadway and Franklin Street, Broadway and Leonard Street, John Moffat, Moffat's Life Pills and Phoenix Bitters, Moffat's Pills, New York: An illustrated History, oldest photograph of New York City, Ric Burns